S-3-hydroxyphenyl (N-hydroxycarbamamido) (diphenyl) ethanethioate derivatives as potential inhibitors of 5 -Lipoxygenase (5-LOX) (#1222)
Read ArticleDate of Conference
July 19-21, 2023
Published In
"Leadership in Education and Innovation in Engineering in the Framework of Global Transformations: Integration and Alliances for Integral Development"
Location of Conference
Buenos Aires
Authors
Ariza-Rua, Danilo
Rebollo, Juan Alberto
Chavarro-Mesa, Edisson
Ballestas-Casallas, Yamil
Abstract
We have designed and docked derivatives of a new anti-inflammatory compound into the crystal structure of the Lipoxygenase-5 (LOX-5) enzyme. We found that four derivatives have the same ability to inhibit the activity of the enzyme as the anti-inflammatory drug Zileuton. This information may help us develop new compounds to treat inflammation.