Production and coproduction of carbapenemases in Enterobacterales isolated from patients in a Peruvian hospital treated during the COVID-19 pandemic. (#883)

Authors

García-Cedrón, David

Cabanillas-Chirinos, Luis A.

De La Cruz Noriega, Magaly

Benites, Santiago M.

Abstract

In Peru, from May 2021 to March 2022, hospital care was restricted due to the second and third wave of the COVID-19 pandemic. During this period a large number of cases of acute respiratory infections increased. With increasing resistance to antibacterials, the search for and identification of carbapenemase co-producing Enterobacteriaceae is of paramount therapeutic importance because it limits the use of available antibiotics. Objective: To determine the Enterobacterales species that present carbapenemase: KPC, NMD and OXA 48 in patients treated in a COVID hospital in Trujillo-Peru, during the COVID-19 pandemic. Methodology: In this descriptive, observational study, biological samples were collected from patients treated in general medicine, emergency, and intensive care units - ICU of Hospital IV "Víctor Lazarte Echegaray" for bacterial identification and sensitivity to carbapenems. removed AutoScan-4 automated system, and the rapid diagnostic immunochromatographic tests RESISIT-3 OKN K-SET were used to determine the type of carbapenemase present in each culture. Results: Of a total of 134 Enterobacterales cultures, Klebsiella pneumoniae is the one with the highest resistance to imipenem and meropenem; the highest prevalence of resistance for both carbapenems was obtained in the ICU (n=22; 54.6%) compared to that obtained in general and emergency medicine.