Preparation of Gelatin/Polyvinyl alcohol decorated with WO3 for cartilage regeneration (#1949)

Authors

Catzim-Ríos, Kevin

Soria, Cintya

Rocha-Pizaña, Maria

Ortega-Lara, Wendy de Lourdes

Abstract

Ceramic particles have been widely used in developing new materials with biomedical applications. However, no material has been found that can match the properties of natural tissues and organs, so considering the evaluation of different ceramic particles for biological fines could help meet the current needs of the materials to be developed. Tungsten trioxide (WO3) is a peculiar ceramic particle since various investigations have shown that, in addition to its use in piezoelectric devices, it has anti-carcinogenic properties at low concentrations and promotes bioactivity on the surfaces of inert materials. In this paper, WO3 nanoparticles have been synthesized by an acid precipitation method supported by a hydrothermal treatment. The obtained particles were used to evaluate their cytotoxicity using a cell viability test in cell lines belonging to fibroblasts and osteoblasts. The best concentration was 31 µg/ml. On the other hand, at the concentrations used, WO3 did not increase cell death. Instead, it promoted bioactivity, so it is presented as a material that could be used with biomedical applications.