Vibrational detection of acetaminophen in commercials tablets by ATR-FTIR spectroscopy and Chemometrics

Published in: Global Partnerships for Development and Engineering Education: Proceedings of the 15th LACCEI International Multi-Conference for Engineering, Education and Technology
Date of Conference: July 19-21, 2017
Location of Conference: Boca Raton, FL, United States
Authors: John R. Castro-Suarez, (Fundación Tecnológica Antonio de Arévalo, CO)
Full Paper: #319

Abstract:

Acetaminophen (AAP) is active ingredient very used in many pharmaceutical preparations. AAP is a pain reliever and a fever reducer drug. Generally, it is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. Standard methods most used for AAP chemical detection are based on chromatography and spectrophotometry techniques, these methods generally imply a sample preparation step, while FTIR based methods do not. Hence, an analytical methods based on IR spectroscopy are very important for the pharmaceutical industry and law enforcement agency, given that allow obtain a way easy and fast molecular information for its detection. In effort for attaining a reliable identification procedure for qualitative determination of AAP in different pharmaceuticals product, an additional chemometrics treatment of ATR-FTIR data is proposed. The proposed method was tested on solid samples containing API. The statistical routine of principal component analysis (PCA) yielded excellent results. The results show that the multivariate sensor is useful for detection of AAP in the drugs tested. Using the proposed method allowed to know if drug is present as desired product or it is counterfeit drugs.